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Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
Trinh, Michael N; Lu, Feiran; Li, Xiaochun; Das, Akash; Liang, Qiren; De Brabander, Jef K; Brown, Michael S; Goldstein, Joseph L.
Affiliation
  • Trinh MN; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Lu F; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Li X; Laboratory of Cell Biology, The Rockefeller University, New York, NY 10065.
  • Das A; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065.
  • Liang Q; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • De Brabander JK; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Brown MS; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Goldstein JL; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390; mike.brown@utsouthwestern.edu joe.goldstein@utsouthwestern.edu.
Proc Natl Acad Sci U S A ; 114(1): 89-94, 2017 01 03.
Article in En | MEDLINE | ID: mdl-27994139
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Biological Transport / Membrane Glycoproteins / Carrier Proteins / Cholesterol / Lysosomes Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Biological Transport / Membrane Glycoproteins / Carrier Proteins / Cholesterol / Lysosomes Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Document type: Article Country of publication: United States