Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells.
J Cancer
; 7(15): 2341-2345, 2016.
Article
in En
| MEDLINE
| ID: mdl-27994673
ABSTRACT
Antimicrobial peptides are an ancient family of molecules that emerged millions of years ago and have been strongly conserved during the evolutionary process of living organisms. Recently, our group described that the human antimicrobial peptide LL-37 migrates to the nucleus, raising the possibility that LL-37 could directly modulate transcription under certain conditions. Here, we showed evidence that LL-37 binds to gene promoter regions, and LL-37 gene silencing changed the transcriptional program of melanoma A375 cells genes associated with histone, metabolism, cellular stress, ubiquitination and mitochondria.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Cancer
Year:
2016
Document type:
Article
Affiliation country:
Brazil
Publication country:
AU
/
AUSTRALIA
/
AUSTRÁLIA