Acromegaly, genetic variants of the aryl hydrocarbon receptor pathway and environmental burden.
Mol Cell Endocrinol
; 457: 81-88, 2017 Dec 05.
Article
in En
| MEDLINE
| ID: mdl-27998805
ABSTRACT
Increasing evidence suggests that environmental contaminants can exert endocrine disruptors activities and that pollution exposition can have a role in tumorigenic processes. Several environmental pollutants have been shown to affect pituitary cells biology and function. The aryl hydrocarbon receptor (AHR) pathway is involved in xenobiotics' metabolism and in tumorigenesis. A deregulation of the AHR pathway could have a role in pituitary tumours' pathophysiology, especially in the GH secreting ones. AHR-interacting protein (AIP) is one of the key partners of AHR and is implicated in pituitary tumours' pathogenesis. Moreover, an increased prevalence of acromegaly has been reported in a highly polluted area of the province of Messina (Sicily, Italy). Nevertheless, at present, few data are available about the potential role of environmental factors in the pathogenesis and clinical expression of GH secreting pituitary tumours. This review is aimed at discussing the evidences on the potential links among environmental pollutants, the AHR pathway and the pathophysiology of GH-secreting pituitary adenomas.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Variation
/
Acromegaly
/
Receptors, Aryl Hydrocarbon
/
Environment
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Mol Cell Endocrinol
Year:
2017
Document type:
Article
Affiliation country:
Italy