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Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.
Rook, Jerri M; Abe, Masahito; Cho, Hyekyung P; Nance, Kellie D; Luscombe, Vincent B; Adams, Jeffrey J; Dickerson, Jonathan W; Remke, Daniel H; Garcia-Barrantes, Pedro M; Engers, Darren W; Engers, Julie L; Chang, Sichen; Foster, Jarrett J; Blobaum, Anna L; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W.
Affiliation
  • Rook JM; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Abe M; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Cho HP; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Nance KD; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Luscombe VB; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Adams JJ; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Dickerson JW; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Remke DH; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Garcia-Barrantes PM; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Engers DW; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Engers JL; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Chang S; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Foster JJ; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Blobaum AL; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Niswender CM; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Jones CK; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Conn PJ; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
  • Lindsley CW; Department of Pharmacology, ‡Department of Chemistry, §Vanderbilt Center for Neuroscience Drug Discovery, ∥Vanderbilt Kennedy Center, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-6600, United States.
ACS Chem Neurosci ; 8(4): 866-883, 2017 04 19.
Article in En | MEDLINE | ID: mdl-28001356
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscarinic Agonists / Receptor, Muscarinic M1 / Allosteric Regulation / Drug Discovery Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: ACS Chem Neurosci Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscarinic Agonists / Receptor, Muscarinic M1 / Allosteric Regulation / Drug Discovery Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: ACS Chem Neurosci Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States