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Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways.
Draijer, Christina; Boorsma, Carian E; Robbe, Patricia; Timens, Wim; Hylkema, Machteld N; Ten Hacken, Nick H; van den Berge, Maarten; Postma, Dirkje S; Melgert, Barbro N.
Affiliation
  • Draijer C; Department of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Boorsma CE; Department of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Robbe P; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Timens W; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Hylkema MN; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Ten Hacken NH; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • van den Berge M; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Postma DS; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Melgert BN; Department of Pharmacokinetics, Toxicology, and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Elect
J Allergy Clin Immunol ; 140(1): 280-283.e3, 2017 07.
Article in En | MEDLINE | ID: mdl-28007476
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Interleukin-10 / Receptors, Cell Surface / Lectins, C-Type / Mannose-Binding Lectins / Interferon Regulatory Factors / Macrophages Type of study: Diagnostic_studies / Observational_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Allergy Clin Immunol Year: 2017 Document type: Article Affiliation country: Netherlands Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Interleukin-10 / Receptors, Cell Surface / Lectins, C-Type / Mannose-Binding Lectins / Interferon Regulatory Factors / Macrophages Type of study: Diagnostic_studies / Observational_studies Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Allergy Clin Immunol Year: 2017 Document type: Article Affiliation country: Netherlands Country of publication: United States