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Mitigation of reactive metabolite formation for a series of 3-amino-2-pyridone inhibitors of Bruton's tyrosine kinase (BTK).
Lou, Yan; Lopez, Francisco; Jiang, Yongying; Han, Xiaochun; Brotherton, Chris; Billedeau, Roland; Gabriel, Steve; Gleason, Shelly; Goldstein, David M; Hilgenkamp, Ramona; Kocer, Buelent; Orzechowski, Lucja; Tan, Jenny; Wovkulich, Peter; Wen, Bo; Fry, David; Di Lello, Paola; Chen, Lucy; Zhang, Fang-Jie; Fretland, Jennifer; Nangia, Anjali; Yang, Tian; Owens, Timothy D.
Affiliation
  • Lou Y; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States. Electronic address: yan.lou@gmail.com.
  • Lopez F; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Jiang Y; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Han X; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Brotherton C; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Billedeau R; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Gabriel S; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Gleason S; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Goldstein DM; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Hilgenkamp R; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Kocer B; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Orzechowski L; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Tan J; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Wovkulich P; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Wen B; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Fry D; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Di Lello P; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Chen L; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Zhang FJ; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Fretland J; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Nangia A; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Yang T; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
  • Owens TD; Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, 340 Kingsland Street, Nutley 07110, United States.
Bioorg Med Chem Lett ; 27(3): 632-635, 2017 02 01.
Article in En | MEDLINE | ID: mdl-28025004
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Protein-Tyrosine Kinases / Protein Kinase Inhibitors Type of study: Prognostic_studies Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Protein-Tyrosine Kinases / Protein Kinase Inhibitors Type of study: Prognostic_studies Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Document type: Article Country of publication: United kingdom