Isoflavin-ß modifies muscle oxidative stress and prevents a thyrotoxicosis-induced loss of muscle mass in rats.
Muscle Nerve
; 56(5): 975-981, 2017 Nov.
Article
in En
| MEDLINE
| ID: mdl-28029692
ABSTRACT
INTRODUCTION:
We sought to verify whether isoflavin-beta (Iso-ß), a mixture of isoflavones with antioxidant properties, could prevent thyrotoxicosis-induced loss of muscle mass and the participation of oxidative stress (OS) in the mechanisms of this prevention.METHODS:
Two experimental periods of thyrotoxicosis induction were used in Wistar rats 3 and 5 days to assess Iso-ß effects before and after thyrotoxicosis-induced muscle wasting. After euthanasia, peritoneal fat and gastrocnemius muscle were collected, weighed, and muscle OS was assessed.RESULTS:
Iso-ß prevented the loss of gastrocnemius mass in thyrotoxic rats through the prevention of muscle OS generation during thyrotoxicosis, increasing muscle total antioxidant capacity and decreasing mitochondrial cytochrome c oxidase activity, lipid peroxidation, and protein carbonyl content.CONCLUSION:
Iso-ß decreased oxidative modification of proteins, which is known to exert a major role during proteolysis induction and is present in thyrotoxic myopathy, highlighting the potential action of Iso-ß in this complication of the disease. Muscle Nerve 56 975-981, 2017.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyrotoxicosis
/
Oxidative Stress
/
Isoflavones
/
Antioxidants
Limits:
Animals
Language:
En
Journal:
Muscle Nerve
Year:
2017
Document type:
Article
Affiliation country:
Brazil