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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells.
Saenz, D T; Fiskus, W; Qian, Y; Manshouri, T; Rajapakshe, K; Raina, K; Coleman, K G; Crew, A P; Shen, A; Mill, C P; Sun, B; Qiu, P; Kadia, T M; Pemmaraju, N; DiNardo, C; Kim, M-S; Nowak, A J; Coarfa, C; Crews, C M; Verstovsek, S; Bhalla, K N.
Affiliation
  • Saenz DT; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Fiskus W; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Qian Y; Arvinas LLC, New Haven, CT, USA.
  • Manshouri T; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Rajapakshe K; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
  • Raina K; Arvinas LLC, New Haven, CT, USA.
  • Coleman KG; Arvinas LLC, New Haven, CT, USA.
  • Crew AP; Arvinas LLC, New Haven, CT, USA.
  • Shen A; Arvinas LLC, New Haven, CT, USA.
  • Mill CP; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Sun B; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Qiu P; Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA, USA.
  • Kadia TM; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Pemmaraju N; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • DiNardo C; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Kim MS; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Nowak AJ; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
  • Coarfa C; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
  • Crews CM; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
  • Verstovsek S; Department of Chemistry, Yale University, New Haven, CT, USA.
  • Bhalla KN; Department of Pharmacology, Yale University, New Haven, CT, USA.
Leukemia ; 31(9): 1951-1961, 2017 09.
Article in En | MEDLINE | ID: mdl-28042144
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Thalidomide / Transcription Factors / Nuclear Proteins / Leukemia, Myeloid, Acute / Myeloproliferative Disorders Limits: Animals / Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Thalidomide / Transcription Factors / Nuclear Proteins / Leukemia, Myeloid, Acute / Myeloproliferative Disorders Limits: Animals / Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom