Effect of Extent of Supersaturation on the Evolution of Kinetic Solubility Profiles.

Han, Yi Rang; Lee, Ping I

Han, Yi Rang; Lee, Ping I.

Affiliation

Han YR; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada.
Lee PI; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada.

Mol Pharm ; 14(1): 206-220, 2017 01 03.

Article in En | MEDLINE | ID: mdl-28043130

Subject(s)

Indomethacin/chemistry; Naproxen/chemistry; Polymers/chemistry; Biological Availability; Chemistry, Pharmaceutical/methods; Crystallization/methods; Drug Liberation/physiology; Kinetics; Solubility

Key words

amorphous solid dispersion; critical supersaturation; extent of supersaturation; kinetic solubility; nucleation and crystallization; poorly water-soluble drug; sink index

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymers / Indomethacin / Naproxen Type of study: Prognostic_studies Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2017 Document type: Article Affiliation country: Canada Country of publication: United States

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