DNA Methylation Profiles of Selected Pro-Inflammatory Cytokines in Alzheimer Disease.
J Neuropathol Exp Neurol
; 76(1): 27-31, 2017 01 01.
Article
in En
| MEDLINE
| ID: mdl-28053004
By means of functional genomics analysis, we recently described the mRNA expression profiles of various genes involved in the neuroinflammatory response in the brains of subjects with late-onset Alzheimer Disease (LOAD). Some of these genes, namely interleukin (IL)-1ß and IL-6, showed distinct expression profiles with peak expression during the first stages of the disease and control-like levels at later stages. IL-1ß and IL-6 genes are modulated by DNA methylation in different chronic and degenerative diseases; it is also well known that LOAD may have an epigenetic basis. Indeed, we and others have previously reported gene-specific DNA methylation alterations in LOAD and in related animal models. Based on these data, we studied the DNA methylation profiles, at single cytosine resolution, of IL-1ß and IL-6 5'-flanking region by bisulphite modification in the cortex of healthy controls and LOAD patients at 2 different disease stages: Braak I-II/A and Braak V-VI/C. Our analysis provides evidence that neuroinflammation in LOAD is associated with (and possibly mediated by) epigenetic modifications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cytokines
/
Inflammation Mediators
/
DNA Methylation
/
Gene Expression Profiling
/
Alzheimer Disease
Limits:
Aged
/
Aged80
/
Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
J Neuropathol Exp Neurol
Year:
2017
Document type:
Article
Affiliation country:
Italy
Country of publication:
United kingdom