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CRYPTOCHROME mediates behavioral executive choice in response to UV light.
Baik, Lisa S; Fogle, Keri J; Roberts, Logan; Galschiodt, Alexis M; Chevez, Joshua A; Recinos, Yocelyn; Nguy, Vinh; Holmes, Todd C.
Affiliation
  • Baik LS; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
  • Fogle KJ; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
  • Roberts L; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
  • Galschiodt AM; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
  • Chevez JA; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
  • Recinos Y; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
  • Nguy V; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
  • Holmes TC; Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697 tholmes@uci.edu.
Proc Natl Acad Sci U S A ; 114(4): 776-781, 2017 01 24.
Article in En | MEDLINE | ID: mdl-28062690
ABSTRACT
Drosophila melanogaster CRYPTOCHROME (CRY) mediates behavioral and electrophysiological responses to blue light coded by circadian and arousal neurons. However, spectroscopic and biochemical assays of heterologously expressed CRY suggest that CRY may mediate functional responses to UV-A (ultraviolet A) light as well. To determine the relative contributions of distinct phototransduction systems, we tested mutants lacking CRY and mutants with disrupted opsin-based phototransduction for behavioral and electrophysiological responses to UV light. CRY and opsin-based external photoreceptor systems cooperate for UV light-evoked acute responses. CRY mediates behavioral avoidance responses related to executive choice, consistent with its expression in central brain neurons.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Choice Behavior / Cryptochromes Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Choice Behavior / Cryptochromes Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2017 Document type: Article