A single, low dose of a cGMP recombinant BCG vaccine elicits protective T cell immunity against the human respiratory syncytial virus infection and prevents lung pathology in mice.

Céspedes, Pablo F; Rey-Jurado, Emma; Espinoza, Janyra A; Rivera, Claudia A; Canedo-Marroquín, Gisela; Bueno, Susan M; Kalergis, Alexis M

Céspedes, Pablo F; Rey-Jurado, Emma; Espinoza, Janyra A; Rivera, Claudia A; Canedo-Marroquín, Gisela; Bueno, Susan M; Kalergis, Alexis M.

Affiliation

Céspedes PF; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile.
Rey-Jurado E; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile.
Espinoza JA; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile.
Rivera CA; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile.
Canedo-Marroquín G; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile.
Bueno SM; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile.
Kalergis AM; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile; Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile; INSERM UM

Vaccine ; 35(5): 757-766, 2017 02 01.

Article in En | MEDLINE | ID: mdl-28065474

Subject(s)

BCG Vaccine/administration & dosage; CD8-Positive T-Lymphocytes/drug effects; Immunity, Cellular/drug effects; Respiratory Syncytial Virus Infections/prevention & control; Respiratory Syncytial Virus Vaccines/administration & dosage; Respiratory Syncytial Virus, Human/drug effects; Th17 Cells/drug effects; Animals; BCG Vaccine/genetics; BCG Vaccine/immunology; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/virology; Humans; Immunization Schedule; Immunogenicity, Vaccine; Interferon-gamma/biosynthesis; Interferon-gamma/immunology; Interleukin-17/biosynthesis; Interleukin-17/immunology; Lung/drug effects; Lung/immunology; Lung/virology; Lymphocyte Activation/drug effects; Mice; Mice, Inbred BALB C; Nucleoproteins/genetics; Nucleoproteins/immunology; Respiratory Syncytial Virus Infections/immunology; Respiratory Syncytial Virus Infections/virology; Respiratory Syncytial Virus Vaccines/genetics; Respiratory Syncytial Virus Vaccines/immunology; Respiratory Syncytial Virus, Human/immunology; Respiratory Syncytial Virus, Human/pathogenicity; Th1 Cells/drug effects; Th1 Cells/immunology; Th1 Cells/virology; Th17 Cells/immunology; Th17 Cells/virology; Vaccines, Synthetic; Viral Proteins/genetics; Viral Proteins/immunology

Key words

Bacillus Calmette et Guerin; Human respiratory syncytial virus; Pulmonary inflammation; Recombinant vaccine; T cells; Th1; Th17; Viral infection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: BCG Vaccine / Respiratory Syncytial Virus, Human / Respiratory Syncytial Virus Infections / CD8-Positive T-Lymphocytes / Respiratory Syncytial Virus Vaccines / Th17 Cells / Immunity, Cellular Language: En Journal: Vaccine Year: 2017 Document type: Article Affiliation country: Chile Country of publication: Netherlands

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