Tamoxifen and its active metabolites inhibit dopamine transporter function independently of the estrogen receptors.

Mikelman, Sarah R; Guptaroy, Bipasha; Gnegy, Margaret E

Mikelman, Sarah R; Guptaroy, Bipasha; Gnegy, Margaret E.

Affiliation

Mikelman SR; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Guptaroy B; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Gnegy ME; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

J Neurochem ; 141(1): 31-36, 2017 04.

Article in En | MEDLINE | ID: mdl-28075498

Subject(s)

Dopamine Plasma Membrane Transport Proteins/antagonists & inhibitors; Dopamine Plasma Membrane Transport Proteins/physiology; Receptors, Estrogen/antagonists & inhibitors; Receptors, Estrogen/physiology; Tamoxifen/metabolism; Tamoxifen/pharmacology; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Estrogen Antagonists/metabolism; Estrogen Antagonists/pharmacology; Humans; Mice; Selective Estrogen Receptor Modulators/metabolism; Selective Estrogen Receptor Modulators/pharmacology

Key words

amphetamine; dopamine transporter; estrogen receptor; tamoxifen

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tamoxifen / Receptors, Estrogen / Dopamine Plasma Membrane Transport Proteins Limits: Animals / Humans Language: En Journal: J Neurochem Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom

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