Step by Step, Cell by Cell: Quantification of the Bacterial Cell Cycle.
Trends Microbiol
; 25(4): 250-256, 2017 04.
Article
in En
| MEDLINE
| ID: mdl-28094092
ABSTRACT
The Escherichia coli cell cycle is a classic, but we are still missing some of its essential aspects. The reason is that our knowledge is mostly based on population data, and our grasp of the behavior of single cells is still very limited. Today, new dynamic single-cell data promise to overcome this barrier. Existing data from single cells have already led to findings and hypotheses that challenge standard views, and have raised new questions. Here, we review these recent developments and propose that a systematic exploration of the correlation patterns between 'cell-cycle intervals' defined by key molecular events measured in many single cells could lead to a quantitative characterization of the cell cycle in terms of inherent stochasticity and homeostatic controls.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Division
/
DNA Replication
/
Escherichia coli
/
Single-Cell Analysis
Language:
En
Journal:
Trends Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Italy