Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.

Wu, Chuan-Jin; Feng, Xu; Lu, Michael; Morimura, Sohshi; Udey, Mark C

Wu, Chuan-Jin; Feng, Xu; Lu, Michael; Morimura, Sohshi; Udey, Mark C.

J Clin Invest ; 127(2): 623-634, 2017 Feb 01.

Article in En | MEDLINE | ID: mdl-28094766

Subject(s)

Claudins/metabolism; Epithelial Cell Adhesion Molecule/metabolism; Intestinal Mucosa/metabolism; Membrane Proteins/metabolism; Serine Endopeptidases/metabolism; Animals; Caco-2 Cells; Claudins/genetics; Epithelial Cell Adhesion Molecule/genetics; Humans; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Membrane Proteins/genetics; Mice; Protein Stability; Serine Endopeptidases/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine Endopeptidases / Claudins / Epithelial Cell Adhesion Molecule / Intestinal Mucosa / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2017 Document type: Article Country of publication: United States

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