Continuous physostigmine infusion in rats with excitotoxic lesions of the nucleus basalis magnocellularis: effects on performance in the water maze task and cortical cholinergic markers.

Mandel, R J; Chen, A D; Connor, D J; Thal, L J

Mandel, R J; Chen, A D; Connor, D J; Thal, L J.

Affiliation

Mandel RJ; Neurology Service Veteran's Administration Medical Center, San Diego, California.

J Pharmacol Exp Ther ; 251(2): 612-9, 1989 Nov.

Article in En | MEDLINE | ID: mdl-2810114

Subject(s)

Basal Ganglia/physiology; Cerebral Cortex/drug effects; Learning/drug effects; Memory/drug effects; Parasympathetic Nervous System/drug effects; Physostigmine/administration & dosage; Substantia Innominata/physiology; Acetylcholinesterase/analysis; Alzheimer Disease/drug therapy; Animals; Cerebral Cortex/enzymology; Choline O-Acetyltransferase/analysis; Infusions, Intravenous; Male; Physostigmine/pharmacology; Rats; Rats, Inbred F344; Receptors, Muscarinic/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Parasympathetic Nervous System / Physostigmine / Substantia Innominata / Basal Ganglia / Cerebral Cortex / Learning / Memory Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 1989 Document type: Article Country of publication: United States

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