Beta-adrenergic antagonist propranolol inhibits mammalian cell lysosome spreading and invasion by Trypanosoma cruzi metacyclic forms.
Microbes Infect
; 19(4-5): 295-301, 2017.
Article
in En
| MEDLINE
| ID: mdl-28111357
ABSTRACT
The involvement of ß-adrenergic receptor (ß-AR) in host cell invasion by Trypanosoma cruzi metacyclic trypomastigote (MT) is not known. We examined whether isoproterenol, an agonist of ß-AR, or nonselective ß-blocker propranolol affected MT internalization mediated the stage-specific surface molecule gp82. Treatment of HeLa cells with propranolol significantly inhibited MT invasion whereas isoproterenol had no effect. Propranolol, but not isoproterenol, also inhibited the lysosome spreading required for gp82-dependent MT invasion. The effect of propranolol in inhibiting MT internalization was not due to the prevention of gp82 interaction with ß-AR. It was mainly associated with its ability to impair lysosome spreading.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Propranolol
/
Trypanosoma cruzi
/
Adrenergic beta-Agonists
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Adrenergic beta-Antagonists
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Isoproterenol
/
Lysosomes
Limits:
Humans
Language:
En
Journal:
Microbes Infect
Journal subject:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
Year:
2017
Document type:
Article
Affiliation country:
Brazil