Optogenetic inhibition of behavior with anion channelrhodopsins.
Nat Methods
; 14(3): 271-274, 2017 03.
Article
in En
| MEDLINE
| ID: mdl-28114289
ABSTRACT
Optogenetics uses light exposure to manipulate physiology in genetically modified organisms. Abundant tools for optogenetic excitation are available, but the limitations of current optogenetic inhibitors present an obstacle to demonstrating the necessity of neuronal circuits. Here we show that anion channelrhodopsins can be used to specifically and rapidly inhibit neural systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, thus demonstrating their broad utility in the circuit analysis of behavior.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhodopsin
/
Behavior, Animal
/
Drosophila
/
Optogenetics
/
Neural Pathways
Limits:
Animals
Language:
En
Journal:
Nat Methods
Journal subject:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Year:
2017
Document type:
Article
Affiliation country:
Singapore