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Association study between the neurexin-1 gene and tardive dyskinesia.
Lanning, Rachel; Lett, Tristram A; Tiwari, Arun K; Brandl, Eva J; de Luca, Vincenzo; Voineskos, Aristotle N; Potkin, Steven G; Lieberman, Jeffrey A; Meltzer, Herbert Y; Müller, Daniel J; Remington, Gary; Kennedy, James L; Zai, Clement C.
Affiliation
  • Lanning R; Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Lett TA; Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Tiwari AK; Department of Psychiatry, Charité University Medicine Berlin, Berlin, Germany.
  • Brandl EJ; Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • de Luca V; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Voineskos AN; Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Potkin SG; Department of Psychiatry, Charité University Medicine Berlin, Berlin, Germany.
  • Lieberman JA; Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Meltzer HY; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Müller DJ; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
  • Remington G; Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Kennedy JL; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Zai CC; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Hum Psychopharmacol ; 32(1)2017 01.
Article in En | MEDLINE | ID: mdl-28120489
ABSTRACT

OBJECTIVE:

Tardive dyskinesia (TD) is a motor side effect that may develop after long-term antipsychotic treatment. Schizophrenia has recently been associated with the Neurexin-1 (NRXN1) gene that codes for a cell adhesion molecule in synaptic communication.

METHODS:

This study examined five NRXN1 single-nucleotide polymorphisms (SNPs) for possible association with the occurrence and severity of TD in 178 schizophrenia patients of European ancestry.

RESULTS:

We did not find these SNPs to be significantly associated with TD.

CONCLUSIONS:

More research is needed with additional SNPs and in bigger samples before we can completely rule out the role of NRXN1 in TD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Antipsychotic Agents / Cell Adhesion Molecules, Neuronal / Polymorphism, Single Nucleotide / Genetic Association Studies / Tardive Dyskinesia / Nerve Tissue Proteins Type of study: Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Hum Psychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2017 Document type: Article Affiliation country: Canada
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Antipsychotic Agents / Cell Adhesion Molecules, Neuronal / Polymorphism, Single Nucleotide / Genetic Association Studies / Tardive Dyskinesia / Nerve Tissue Proteins Type of study: Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Hum Psychopharmacol Journal subject: PSICOFARMACOLOGIA Year: 2017 Document type: Article Affiliation country: Canada