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Evaluation of relative MS response factors of drug metabolites for semi-quantitative assessment of chemical liabilities in drug discovery.
Blanz, Joachim; Williams, Gareth; Dayer, Jerôme; Délémonté, Thierry; Gertsch, Werner; Ramstein, Philippe; Aichholz, Reiner; Trunzer, Markus; Pearson, David.
Affiliation
  • Blanz J; Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, Postfach, Basel, CH-4002, Switzerland.
  • Williams G; Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, Postfach, Basel, CH-4002, Switzerland.
  • Dayer J; Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, Postfach, Basel, CH-4002, Switzerland.
  • Délémonté T; Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, Postfach, Basel, CH-4002, Switzerland.
  • Gertsch W; Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, Postfach, Basel, CH-4002, Switzerland.
  • Ramstein P; Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, Postfach, Basel, CH-4002, Switzerland.
  • Aichholz R; Analytical Sciences and Imaging, Novartis Institutes for Biomedical Research, Postfach, Basel, CH-4002, Switzerland.
  • Trunzer M; Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, Postfach, Basel, CH-4002, Switzerland.
  • Pearson D; DMPK, Novartis Institutes for Biomedical Research, Postfach, Basel, CH-4002, Switzerland.
J Mass Spectrom ; 52(4): 210-217, 2017 04.
Article in En | MEDLINE | ID: mdl-28152561
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Drug Discovery Type of study: Evaluation_studies / Prognostic_studies Limits: Humans Language: En Journal: J Mass Spectrom Journal subject: BIOQUIMICA Year: 2017 Document type: Article Affiliation country: Switzerland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Drug Discovery Type of study: Evaluation_studies / Prognostic_studies Limits: Humans Language: En Journal: J Mass Spectrom Journal subject: BIOQUIMICA Year: 2017 Document type: Article Affiliation country: Switzerland