Utilizing online-dual-SPE-LC with HRMS for the simultaneous quantification of amphotericin B, fluconazole, and fluorocytosine in human plasma and cerebrospinal fluid.

Qu, Lihua; Qian, Jing; Ma, Ping; Yin, Zheng

Qu, Lihua; Qian, Jing; Ma, Ping; Yin, Zheng.

Affiliation

Qu L; Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
Qian J; Infectious Diseases Dependent, Tianjin Second People's Hospital, Tianjin 300192, PR China.
Ma P; Infectious Diseases Dependent, Tianjin Second People's Hospital, Tianjin 300192, PR China. Electronic address: mapingtianjin@163.com.
Yin Z; Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084, PR China. Electronic address: yinzheng@mail.tsinghua.edu.cn.

Talanta ; 165: 449-457, 2017 Apr 01.

Article in En | MEDLINE | ID: mdl-28153282

Subject(s)

Amphotericin B/analysis; Chromatography, Liquid/methods; Drug Monitoring/methods; Fluconazole/analysis; Flucytosine/analysis; Solid Phase Extraction/methods; Tandem Mass Spectrometry/methods; Amphotericin B/blood; Amphotericin B/cerebrospinal fluid; Antifungal Agents/analysis; Antifungal Agents/blood; Antifungal Agents/cerebrospinal fluid; Fluconazole/blood; Fluconazole/cerebrospinal fluid; Flucytosine/blood; Flucytosine/cerebrospinal fluid; Humans; Online Systems

Key words

HIV-CM; Human plasma and CSF; Online-dual-SPE-LC-HRMS; Stop-flow heart-cutting 2D

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fluconazole / Amphotericin B / Chromatography, Liquid / Drug Monitoring / Tandem Mass Spectrometry / Solid Phase Extraction / Flucytosine Type of study: Guideline Limits: Humans Language: En Journal: Talanta Year: 2017 Document type: Article Country of publication: Netherlands

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