Your browser doesn't support javascript.
loading
Omega-3 fatty acids and cytochrome P450-derived eicosanoids in cardiovascular diseases: Which actions and interactions modulate hemodynamics?
Bonafini, Sara; Fava, Cristiano.
Affiliation
  • Bonafini S; University of Verona, Department of Medicine, General Medicine and Hypertension Unit, Italy.
  • Fava C; University of Verona, Department of Medicine, General Medicine and Hypertension Unit, Italy. Electronic address: cristiano.fava@univr.it.
Prostaglandins Other Lipid Mediat ; 128-129: 34-42, 2017 01.
Article in En | MEDLINE | ID: mdl-28167220
Increasing interest is focused on omega-3 fatty acids (FA) because of their potential beneficial effects, particularly in cardiovascular disease prevention. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two major omega-3 FA, are mainly consumed through diet, particularly from fish and seafood intake, whereas alpha-linolenic acid (ALA) is present in high amounts in leafy green vegetables, nuts and seeds. The hypothesis of a cardiovascular protective action of omega-3 FA derives mainly from observational studies, whereas the evidence from interventional studies is not always consistent. Nonetheless, clinical trials and meta-analyses indicate a positive action, at minimum on blood pressure (BP). Omega-3 FA may act through different biological pathways; however, in our review, we seek to revisit, most notably, the role of their metabolites via cytochrome P450 (CYP450) in hemodynamic modulation. We emphasize that the effect of omega-3 FA may depend on their balance with other dietary compounds, particularly omega-6 FA, which compete for the same pathways, thus modulating the production of metabolites. Furthermore, the biological activity of omega-3 FA might be better explained by the complex balance and interactions between a variety of nutrients and polymorphisms of genes implicated in specific metabolic pathways.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Eicosanoids / Fatty Acids, Omega-3 / Cytochrome P-450 Enzyme System / Hemodynamics Type of study: Observational_studies Limits: Animals / Humans Language: En Journal: Prostaglandins Other Lipid Mediat Journal subject: ENDOCRINOLOGIA Year: 2017 Document type: Article Affiliation country: Italy Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Eicosanoids / Fatty Acids, Omega-3 / Cytochrome P-450 Enzyme System / Hemodynamics Type of study: Observational_studies Limits: Animals / Humans Language: En Journal: Prostaglandins Other Lipid Mediat Journal subject: ENDOCRINOLOGIA Year: 2017 Document type: Article Affiliation country: Italy Country of publication: United States