Simultaneous assay of multiple antibiotics in human plasma by LC-MS/MS: importance of optimizing formic acid concentration.

Chen, Feng; Hu, Zhe-Yi; Laizure, S Casey; Hudson, Joanna Q

Chen, Feng; Hu, Zhe-Yi; Laizure, S Casey; Hudson, Joanna Q.

Affiliation

Chen F; Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Hu ZY; Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Laizure SC; Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Hudson JQ; Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Bioanalysis ; 9(5): 469-483, 2017 Mar.

Article in En | MEDLINE | ID: mdl-28176533

Subject(s)

Anti-Bacterial Agents/blood; Formates/chemistry; Tandem Mass Spectrometry; Chromatography, High Pressure Liquid; Critical Illness; Humans; Limit of Detection

Key words

LCMS/MS; cefepime; daptomycin; formic acid; matrix effects; meropenem; piperacillin/tazobactam; vancomycin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tandem Mass Spectrometry / Formates / Anti-Bacterial Agents Type of study: Guideline Limits: Humans Language: En Journal: Bioanalysis Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom

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