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Aedes aegypti Larvicidal Sesquiterpene Alkaloids from Maytenus oblongata.
Touré, Seindé; Nirma, Charlotte; Falkowski, Michael; Dusfour, Isabelle; Boulogne, Isabelle; Jahn-Oyac, Arnaud; Coke, Maïra; Azam, Didier; Girod, Romain; Moriou, Céline; Odonne, Guillaume; Stien, Didier; Houël, Emeline; Eparvier, Véronique.
Affiliation
  • Touré S; CNRS, Institut de Chimie des Substances Naturelles , 91198 Gif-sur-Yvette, France.
  • Nirma C; CNRS, Institut de Chimie des Substances Naturelles , 91198 Gif-sur-Yvette, France.
  • Falkowski M; CNRS, UMR EcoFoG, AgroParisTech, Cirad, INRA, Université des Antilles, Université de Guyane , 97300 Cayenne, France.
  • Dusfour I; Unité de Contrôle et Adaptation des Vecteurs, Institut Pasteur de la Guyane , 97306 Cayenne, France.
  • Boulogne I; CNRS, UMR EcoFoG, AgroParisTech, Cirad, INRA, Université des Antilles, Université de Guyane , 97300 Cayenne, France.
  • Jahn-Oyac A; UPRES-EA 4358 GlycoMev (Glycobiologie et Matrice Extracellulaire Végétale), Université de Rouen , 76821 Mont-Saint-Aignan, France.
  • Coke M; CNRS, UMR EcoFoG, AgroParisTech, Cirad, INRA, Université des Antilles, Université de Guyane , 97300 Cayenne, France.
  • Azam D; Unité Expérimentale d'Ecologie et d'Ecotoxicologie Aquatique, INRA-U3E , 35042 Rennes, France.
  • Girod R; Unité Expérimentale d'Ecologie et d'Ecotoxicologie Aquatique, INRA-U3E , 35042 Rennes, France.
  • Moriou C; Unité de Contrôle et Adaptation des Vecteurs, Institut Pasteur de la Guyane , 97306 Cayenne, France.
  • Odonne G; CNRS, Institut de Chimie des Substances Naturelles , 91198 Gif-sur-Yvette, France.
  • Stien D; Laboratoire Ecologie, Evolution, Interactions des Systèmes Amazoniens (LEEISA), CNRS, Université de Guyane, IFREMER , 97300 Cayenne, France.
  • Houël E; CNRS, Institut de Chimie des Substances Naturelles , 91198 Gif-sur-Yvette, France.
  • Eparvier V; Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Sorbonne Universités, UPMC Univ. Paris 06, CNRS , Observatoire Océanologique, 66650 Banyuls-sur-Mer, France.
J Nat Prod ; 80(2): 384-390, 2017 02 24.
Article in En | MEDLINE | ID: mdl-28186749
ABSTRACT
Four new sesquiterpene alkaloids (1-4) with a ß-dihydroagrofuran skeleton and a new triterpenoid (5) were isolated from an ethyl acetate extract of Maytenus oblongata stems. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and ECD experiments. The M. oblongata stem EtOAc extract and the pure compounds isolated were tested for larvicidal activity against Aedes aegypti under laboratory conditions, and compounds 2 and 3 were found to be active.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Triterpenes / Aedes / Maytenus / Alkaloids / Larva Limits: Animals Country/Region as subject: America do sul / Guyana francesa Language: En Journal: J Nat Prod Year: 2017 Document type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Triterpenes / Aedes / Maytenus / Alkaloids / Larva Limits: Animals Country/Region as subject: America do sul / Guyana francesa Language: En Journal: J Nat Prod Year: 2017 Document type: Article Affiliation country: France