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Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.
Pipalia, Nina H; Subramanian, Kanagaraj; Mao, Shu; Ralph, Harold; Hutt, Darren M; Scott, Samantha M; Balch, William E; Maxfield, Frederick R.
Affiliation
  • Pipalia NH; Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065; and Department of Chemical Physiology and Cell and Molecular Biology.
  • Subramanian K; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037.
  • Mao S; Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065; and Department of Chemical Physiology and Cell and Molecular Biology.
  • Ralph H; Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065; and Department of Chemical Physiology and Cell and Molecular Biology.
  • Hutt DM; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037.
  • Scott SM; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037.
  • Balch WE; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037. Electronic address: webalch@scripps.edu.
  • Maxfield FR; Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065; and Department of Chemical Physiology and Cell and Molecular Biology,. Electronic address: frmaxfie@med.cornell.edu.
J Lipid Res ; 58(4): 695-708, 2017 04.
Article in En | MEDLINE | ID: mdl-28193631
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Carrier Proteins / Cholesterol / Niemann-Pick Disease, Type C / Histone Deacetylase Inhibitors Limits: Humans Language: En Journal: J Lipid Res Year: 2017 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Carrier Proteins / Cholesterol / Niemann-Pick Disease, Type C / Histone Deacetylase Inhibitors Limits: Humans Language: En Journal: J Lipid Res Year: 2017 Document type: Article Country of publication: United States