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The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology.
Mishra, Jyotsna; Jhun, Bong Sook; Hurst, Stephen; O-Uchi, Jin; Csordás, György; Sheu, Shey-Shing.
Affiliation
  • Mishra J; Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1020 Locust Street, Suite 543D, Philadelphia, PA, 19107, USA.
  • Jhun BS; Cardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
  • Hurst S; Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1020 Locust Street, Suite 543D, Philadelphia, PA, 19107, USA.
  • O-Uchi J; Cardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA. jin.ouchi@lifespan.org.
  • Csordás G; MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA. Gyorgy.Csordas@jefferson.edu.
  • Sheu SS; Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1020 Locust Street, Suite 543D, Philadelphia, PA, 19107, USA. shey-shing.sheu@jefferson.edu.
Handb Exp Pharmacol ; 240: 129-156, 2017.
Article in En | MEDLINE | ID: mdl-28194521
ABSTRACT
Mitochondrial Ca2+ uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca2+ uptake and our current understanding of mitochondrial Ca2+ homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca2+ uniporter complex.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channels Limits: Animals / Humans Language: En Journal: Handb Exp Pharmacol Year: 2017 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channels Limits: Animals / Humans Language: En Journal: Handb Exp Pharmacol Year: 2017 Document type: Article Affiliation country: United States