Ethnic variation in medical and lifestyle risk factors for B cell non-Hodgkin lymphoma: A case-control study among Israelis and Palestinians.
PLoS One
; 12(2): e0171709, 2017.
Article
in En
| MEDLINE
| ID: mdl-28196110
ABSTRACT
BACKGROUND:
Risk factors for B-cell non-Hodgkin lymphoma (B-NHL) have not been assessed among Palestinian Arabs (PA) and Israeli Jews (IJ).METHODS:
In a case-control study we investigated self-reported medical and lifestyle exposures, reporting odds ratios (ORs) and 95% confidence intervals [CIs], by ethnicity, for overall B-NHL and subtypes.RESULTS:
We recruited 823 cases and 808 healthy controls. Among 307 PA/516 IJ B-NHL cases (mean age at diagnosis = 51 [±17] versus 60 [±15] years, respectively) subtype distributions differed, with diffuse large B-cell lymphoma (DLBCL) being prominent among PA (71%) compared to IJ (41%); follicular lymphoma (FL), was observed in 14% versus 28%, and marginal zone lymphoma, in 2% versus 14%, respectively. Overall B-NHL in both populations was associated with recreational sun exposure OR = 1.43 [CI1.07-1.91], black hair-dye use OR = 1.70 [CI1.00-2.87], hospitalization for infection OR = 1.68 [CI1.34-2.11], and first-degree relative with hematopoietic cancer, OR = 1.69 [CI1.16-2.48]. An inverse association was noted with alcohol use, OR = 0.46 [CI0.34-0.62]. Subtype-specific exposures included smoking (FL, OR = 1.46 [CI1.01-2.11]) and >monthly indoor pesticide use (DLBCL, OR = 2.01 [CI1.35-3.00]). Associations observed for overall B-NHL in PA only included gardening OR = 1.93 [CI1.39-2.70]; history of herpes, mononucleosis, rubella, blood transfusion (OR>2.5, P<0.01 for all); while for IJ risk factors included growing fruits and vegetables, OR = 1.87 [CI1.11-3.15]; and self-reported autoimmune diseases, OR = 1.99 [CI1.34-2.95].CONCLUSIONS:
In these geographically proximate populations we found some unique risk factors for B-NHL. Heterogeneity in the observed associations by ethnicity could reflect differences in lifestyle, medical systems, and reporting patterns, while variations by histology infer specific etiologic factors for lymphoma subtypes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphoma, B-Cell
/
Life Style
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Humans
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
PLoS One
Journal subject:
CIENCIA
/
MEDICINA
Year:
2017
Document type:
Article
Affiliation country:
Israel
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA