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Pattern of first- and second-line drug resistance among pulmonary tuberculosis retreatment cases in Pakistan.
Javaid, A; Hasan, R; Zafar, A; Chaudry, M A; Qayyum, S; Qadeer, E; Shaheen, Z; Agha, N; Rizvi, N; Afridi, M Z; Chima, M K; Khan, A R; Ghafoor, A; Khan, S; Awan, S R; Akhtar, S; Choudry, K; Iqbal, Z H; Ansarie, M; Ahmad, N.
Affiliation
  • Javaid A; Department of Pulmonology, Postgraduate Medical Institute, Lady Reading Hospital, Peshawar.
  • Hasan R; Department of Microbiology, Agha Khan University, Karachi.
  • Zafar A; Department of Microbiology, Agha Khan University, Karachi.
  • Chaudry MA; Gulab Devi Chest Hospital, Lahore.
  • Qayyum S; Ojha Institute of Chest Disease, Karachi.
  • Qadeer E; National TB Control Programme, Islamabad.
  • Shaheen Z; Department of Pulmonology, Nishtar Medical College, Multan.
  • Agha N; Fatima Jinnah Chest Hospital, Quetta.
  • Rizvi N; Department of Chest Medicine, Jinnah Postgraduate Medical Centre, Karachi.
  • Afridi MZ; Khyber Medical College, Peshawar.
  • Chima MK; Department of Pulmonology, Services Hospital, Lahore.
  • Khan AR; Department of Pulmonology, Ayub Medical College, Abbottabad.
  • Ghafoor A; Health Department, Peshawar.
  • Khan S; Department of Chest Medicine, Lahore General Hospital, Lahore.
  • Awan SR; Itefaq Medical College, Lahore.
  • Akhtar S; Department of Medicine, Ziauddin University, Karachi.
  • Choudry K; Department of Pulmonology, King Edward Medical University, Lahore.
  • Iqbal ZH; Department of Pulmonology, Allama Iqbal Medical College, Lahore.
  • Ansarie M; Orthopaedic and Medical Institute, Karachi, Pakistan.
  • Ahmad N; Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Int J Tuberc Lung Dis ; 21(3): 303-308, 2017 03 01.
Article in En | MEDLINE | ID: mdl-28225340
ABSTRACT

BACKGROUND:

Drug resistance in general, and multidrug-resistant tuberculosis (MDR-TB) in particular, threatens global tuberculosis (TB) control efforts. Population-based estimates of drug resistance are needed to develop strategies for controlling drug-resistant TB in Pakistan.

OBJECTIVE:

To obtain population-based data on Mycobacterium tuberculosis drug resistance in Pakistan.

METHODS:

To obtain drug resistance data, we conducted a population-based study of TB cases in all provinces of Pakistan. We performed culture and drug susceptibility testing on M. tuberculosis isolates from patients with a prior history of anti-tuberculosis treatment (retreatment cases) from all over the country.

RESULTS:

Of 544 isolates from previously treated cases, 289 (53.1%) were susceptible to all first-line drugs, 255 (46.9%) were resistant to at least one anti-tuberculosis drug and 132 (24.3%) were MDR-TB. Among MDR-TB isolates, 47.0% were ofloxacin (OFX) resistant. Extensively drug-resistant TB was found in two (0.4%) isolates.

CONCLUSION:

Prevalence of drug resistance in retreatment isolates was high. The alarmingly high prevalence of OFX resistance among MDR-TB isolates may threaten the success of efforts to control and treat MDR-TB.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis, Pulmonary / Extensively Drug-Resistant Tuberculosis / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Int J Tuberc Lung Dis Year: 2017 Document type: Article
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis, Pulmonary / Extensively Drug-Resistant Tuberculosis / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Int J Tuberc Lung Dis Year: 2017 Document type: Article