Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach.

Lammers, Laureen A; Achterbergh, Roos; van Schaik, Ron H N; Romijn, Johannes A; Mathôt, Ron A A

Lammers, Laureen A; Achterbergh, Roos; van Schaik, Ron H N; Romijn, Johannes A; Mathôt, Ron A A.

Affiliation

Lammers LA; Department of Hospital Pharmacy, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. l.a.tenberg-lammers@amc.uva.nl.
Achterbergh R; Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
van Schaik RHN; Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands.
Romijn JA; Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Mathôt RAA; Department of Hospital Pharmacy, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Clin Pharmacokinet ; 56(10): 1231-1244, 2017 10.

Article in En | MEDLINE | ID: mdl-28229374

Subject(s)

Cytochrome P-450 CYP1A2/metabolism; Cytochrome P-450 CYP2C9/metabolism; Cytochrome P-450 CYP2D6/metabolism; Fasting/metabolism; Pharmaceutical Preparations/administration & dosage; Pharmaceutical Preparations/metabolism; Administration, Intravenous; Administration, Oral; Adult; Caffeine/administration & dosage; Caffeine/metabolism; Cross-Over Studies; Cytochrome P-450 Enzyme System/metabolism; Drug Combinations; Healthy Volunteers; Humans; Male; Metoprolol/administration & dosage; Metoprolol/metabolism; Midazolam/administration & dosage; Midazolam/metabolism; Omeprazole/administration & dosage; Omeprazole/metabolism; Time Factors; Warfarin/administration & dosage; Warfarin/metabolism; Young Adult

Key words

Caffeine; Mean Transit Time; Metoprolol; Omeprazole; Systemic Clearance

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Fasting / Cytochrome P-450 CYP1A2 / Cytochrome P-450 CYP2D6 / Cytochrome P-450 CYP2C9 Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Humans / Male Language: En Journal: Clin Pharmacokinet Year: 2017 Document type: Article Affiliation country: Netherlands

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google