Dibenzoquinazoline diones as antihypertensive cyclic guanosine monophosphate phosphodiesterase inhibitors.
Biochem Pharmacol
; 36(20): 3517-21, 1987 Oct 15.
Article
in En
| MEDLINE
| ID: mdl-2823824
ABSTRACT
The discovery and structure-activity of a new class of renal artery phosphodiesterase inhibitors is reported, some of which are highly selective for the guanosine cyclic 3',5'-monophosphate phosphodiesterase. One of these compounds, 5,6-dihydro-8,9,11,12-tetramethoxy-1,3-dioxo-1H-benz[f]- isoquino [8,1,2- hij]quinazoline-2(3H)-carboxylic acid, ethyl ester (9), is amongst the most potent and selective compounds of this class yet identified. Furthermore, this compound demonstrates an antihypertensive effect in vivo which is presumably mediated through vascular smooth muscle relaxation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
3',5'-Cyclic-GMP Phosphodiesterases
/
Tetrahydroisoquinolines
/
Isoquinolines
/
Antihypertensive Agents
Limits:
Animals
Language:
En
Journal:
Biochem Pharmacol
Year:
1987
Document type:
Article
Affiliation country:
United kingdom