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Permeation of Polymethoxyflavones into the Mouse Brain and Their Effect on MK-801-Induced Locomotive Hyperactivity.
Okuyama, Satoshi; Miyazaki, Kohei; Yamada, Rie; Amakura, Yoshiaki; Yoshimura, Morio; Sawamoto, Atsushi; Nakajima, Mitsunari; Furukawa, Yoshiko.
Affiliation
  • Okuyama S; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. sokuyama@cc.matsuyama-u.ac.jp.
  • Miyazaki K; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. mu.yakuri.002@gmail.com.
  • Yamada R; Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. 46150023@cc.matsuyama-u.ac.jp.
  • Amakura Y; Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. amakura@cc.matsuyama-u.ac.jp.
  • Yoshimura M; Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. myoshimu@cc.matsuyama-u.ac.jp.
  • Sawamoto A; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. 46140018@cc.matsuyama-u.ac.jp.
  • Nakajima M; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. mnakajim@cc.matsuyama-u.ac.jp.
  • Furukawa Y; Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. furukawa@cc.matsuyama-u.ac.jp.
Int J Mol Sci ; 18(3)2017 Feb 24.
Article in En | MEDLINE | ID: mdl-28245567
Accumulating data have indicated that citrus polymethoxyflavones (PMFs) have the ability to affect brain function. In the present study, we showed that 3,5,6,7,8,3',4'-heptamethoxy- flavone (HMF) given intraperitoneally to mice was immediately detected in the brain and that the permeability of the brain tissues to it was significantly higher than that of other citrus PMFs (nobiletin, tangeretin, and natsudaidain). The permeation of these PMFs into the brain well correlated with their abilities to suppress MK-801-induced locomotive hyperactivity, suggesting that HMF had the ability to act directly in the brain. We also obtained data suggesting that the suppressive effect of HMF on MK-801-induced locomotive hyperactivity was mediated by phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) in the hippocampus.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Plant Extracts / Dizocilpine Maleate / Flavones / Hyperkinesis Limits: Animals Language: En Journal: Int J Mol Sci Year: 2017 Document type: Article Affiliation country: Japan Country of publication: Switzerland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Plant Extracts / Dizocilpine Maleate / Flavones / Hyperkinesis Limits: Animals Language: En Journal: Int J Mol Sci Year: 2017 Document type: Article Affiliation country: Japan Country of publication: Switzerland