Accessing N-Acyl Azoles via Oxoammonium Salt-Mediated Oxidative Amidation.
Org Lett
; 19(6): 1286-1289, 2017 03 17.
Article
in En
| MEDLINE
| ID: mdl-28248527
ABSTRACT
An operationally simple, robust, metal-free approach to the synthesis of N-acyl azoles from both alcohols and aldehydes is described. Oxidative amidation is facilitated by a commercially available organic oxidant (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate) and proceeds under very mild conditions for an array of structurally diverse substrates. Tandem reactions of these activated amides, such as transamidation and esterification, enable further elaboration. Also, the spent oxidant can be recovered and used to regenerate the oxoammonium salt.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2017
Document type:
Article
Affiliation country:
United States