Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C.

Benoit, Roger M; Schärer, Martin A; Wieser, Mara M; Li, Xiaodan; Frey, Daniel; Kammerer, Richard A

Benoit, Roger M; Schärer, Martin A; Wieser, Mara M; Li, Xiaodan; Frey, Daniel; Kammerer, Richard A.

Affiliation

Benoit RM; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Schärer MA; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Wieser MM; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Li X; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Frey D; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Kammerer RA; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.

Sci Rep ; 7: 43588, 2017 03 02.

Article in En | MEDLINE | ID: mdl-28252640

Subject(s)

Botulinum Toxins, Type A/chemistry; Membrane Glycoproteins/chemistry; Nerve Tissue Proteins/chemistry; Protein Interaction Domains and Motifs; Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Botulinum Toxins, Type A/metabolism; Humans; Models, Molecular; Protein Binding; Protein Conformation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Botulinum Toxins, Type A / Protein Interaction Domains and Motifs / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Humans Language: En Journal: Sci Rep Year: 2017 Document type: Article Affiliation country: Switzerland

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