Protein NMR Studies of Substrate Binding to Human Blood GroupâA and B Glycosyltransferases.

Grimm, Lena Lisbeth; Weissbach, Sophie; Flügge, Friedemann; Begemann, Nora; Palcic, Monica M; Peters, Thomas

Protein NMR Studies of Substrate Binding to Human Blood GroupâA and B Glycosyltransferases.

Grimm, Lena Lisbeth; Weissbach, Sophie; Flügge, Friedemann; Begemann, Nora; Palcic, Monica M; Peters, Thomas.

Affiliation

Grimm LL; Institute of Chemistry, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Weissbach S; Institute of Chemistry, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Flügge F; Institute of Chemistry, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Begemann N; Institute of Chemistry, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Palcic MM; Department of Biochemistry and Microbiology, University of Victoria, P. O. Box 3800, STN CSC, Victoria, BC, V8W 3P6, Canada.
Peters T; Institute of Chemistry, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.

Chembiochem ; 18(13): 1260-1269, 2017 07 04.

Article in En | MEDLINE | ID: mdl-28256109

Subject(s)

Galactosyltransferases/chemistry; N-Acetylgalactosaminyltransferases/chemistry; Uridine Diphosphate Galactose/chemistry; Uridine Diphosphate/chemistry; Amino Acid Sequence; Binding Sites; Cloning, Molecular; Escherichia coli/genetics; Escherichia coli/metabolism; Galactosyltransferases/genetics; Galactosyltransferases/metabolism; Gene Expression; Humans; Kinetics; Models, Molecular; N-Acetylgalactosaminyltransferases/genetics; N-Acetylgalactosaminyltransferases/metabolism; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Sequence Alignment; Substrate Specificity; Uridine Diphosphate/metabolism; Uridine Diphosphate Galactose/metabolism

Key words

NMR spectroscopy; blood group antigens; enzyme catalysis; glycosyltransferases; transferases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uridine Diphosphate / Uridine Diphosphate Galactose / N-Acetylgalactosaminyltransferases / Galactosyltransferases Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2017 Document type: Article Affiliation country: Germany Country of publication: Germany

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