Immunoregulatory functions of VISTA.
Immunol Rev
; 276(1): 66-79, 2017 03.
Article
in En
| MEDLINE
| ID: mdl-28258694
ABSTRACT
Utilization of negative checkpoint regulators (NCRs) for cancer immunotherapy has garnered significant interest with the completion of clinical trials demonstrating efficacy. While the results of monotherapy treatments are compelling, there is increasing emphasis on combination treatments in an effort to increase response rates to treatment. One of the most recently discovered NCRs is VISTA (V-domain Ig-containing Suppressor of T cell Activation). In this review, we describe the functions of this molecule in the context of cancer immunotherapy. We also discuss factors that may influence the use of anti-VISTA antibody in combination therapy and how genomic analysis may assist in providing indications for treatment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
B7 Antigens
/
Immunotherapy
/
Antibodies, Monoclonal
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Immunol Rev
Year:
2017
Document type:
Article
Affiliation country:
United States