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Hepatoprotective hemiterpene glycosides from the rhizome of Cibotium barometz (L.) J. Sm.
Xie, Mei-Ping; Li, Lan; Sun, Hua; Lu, An-Qi; Zhang, Bo; Shi, Jian-Gong; Zhang, Dan; Wang, Su-Juan.
Affiliation
  • Xie MP; State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Li L; State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Sun H; State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Lu AQ; State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Zhang B; State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Shi JG; State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Zhang D; State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
  • Wang SJ; State Key Laboratory of Active Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: sujuanwang@imm.ac.cn.
Phytochemistry ; 138: 128-133, 2017 Jun.
Article in En | MEDLINE | ID: mdl-28262248
ABSTRACT
Five previously undescribed hemiterpene glycosides, cibotiumbarosides E-I, and two known hemiterpene glucosides, were isolated from the rhizome of Cibotium barometz (L.) J. Sm. The structures of cibotiumbarosides E-I were established by 1D and 2D NMR spectroscopic analyses and HRMS. The absolute configuration of the aglycone of cibotiumbaroside E was assigned by calculated ECD with the TDDFT method. Cibotiumbarosides F and I both exhibited remarkable hepatoprotective activity against APAP-induced acute liver damage in vitro, which were more effective than the positive control, bicyclol. On the other hand, seven hemiterpene glycosides were all inactive in assays of cytotoxicity, neuroprotection, antidiabetes and anti-inflammation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhizome / Hemiterpenes / Tracheophyta / Glycosides Limits: Humans Language: En Journal: Phytochemistry Year: 2017 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rhizome / Hemiterpenes / Tracheophyta / Glycosides Limits: Humans Language: En Journal: Phytochemistry Year: 2017 Document type: Article Affiliation country: China