The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice.

Qu, Xiao-Yu; Tao, Li-Na; Zhang, Si-Xi; Sun, Jing-Meng; Niu, Jun-Qi; Ding, Yan-Hua; Song, Yan-Qing

Qu, Xiao-Yu; Tao, Li-Na; Zhang, Si-Xi; Sun, Jing-Meng; Niu, Jun-Qi; Ding, Yan-Hua; Song, Yan-Qing.

Affiliation

Qu XY; Depatment of Pharmacy, the First Hospital of Jilin University, Changchun, China.
Tao LN; Depatment of Pharmacy, the First Hospital of Jilin University, Changchun, China.
Zhang SX; Depatment of Pharmacy, the First Hospital of Jilin University, Changchun, China.
Sun JM; Changchun University of Chinese Medicine, Changchun, China.
Niu JQ; Department of Hepatology, the First Hospital of Jilin University, Changchun, China.
Ding YH; Phase I Clinical Trial Unit, the First Hospital of Jilin University, Changchun, China.
Song YQ; Depatment of Pharmacy, the First Hospital of Jilin University, Changchun, China. Electronic address: yanqingyjk@163.com.

Environ Toxicol Pharmacol ; 51: 16-22, 2017 Apr.

Article in En | MEDLINE | ID: mdl-28262508

Subject(s)

ATP-Binding Cassette Transporters/metabolism; Chemical and Drug Induced Liver Injury/metabolism; Dioscorea/chemistry; Drugs, Chinese Herbal/toxicity; Heterocyclic Compounds, 4 or More Rings/toxicity; Multidrug Resistance-Associated Proteins/metabolism; Organic Anion Transporters, Sodium-Dependent/metabolism; Organic Cation Transport Proteins/metabolism; Symporters/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters/genetics; Animals; Chemical and Drug Induced Liver Injury/etiology; Chemical and Drug Induced Liver Injury/pathology; Drugs, Chinese Herbal/isolation & purification; Gene Expression/drug effects; Heterocyclic Compounds, 4 or More Rings/isolation & purification; Lipid Peroxidation/drug effects; Liver/drug effects; Liver/metabolism; Liver/pathology; Male; Mice, Inbred ICR; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins/genetics; Organic Anion Transporters, Sodium-Dependent/genetics; Organic Cation Transport Proteins/genetics; Symporters/genetics

Key words

Bile salt export pump; Diosbulbin B; Dioscorea bulbifera L.; Multidrug resistance associated protein 2; Na+-taurocholate co-transporting polypeptide; Organic anion transporting polypeptide 2

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drugs, Chinese Herbal / ATP-Binding Cassette Transporters / Dioscorea / Multidrug Resistance-Associated Proteins / Organic Anion Transporters, Sodium-Dependent / Organic Cation Transport Proteins / Symporters / Chemical and Drug Induced Liver Injury / Heterocyclic Compounds, 4 or More Rings Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Environ Toxicol Pharmacol Year: 2017 Document type: Article Affiliation country: China Country of publication: Netherlands

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