Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue.
Org Biomol Chem
; 15(12): 2501-2506, 2017 Mar 28.
Article
in En
| MEDLINE
| ID: mdl-28266673
ABSTRACT
The synthesis and in vivo pharmacokinetic profile of an analogue of cyclosporine is disclosed. An acyclic congener was also profiled in in vitro assays to compare cell permeability. The compounds possess similar calculated and measured molecular descriptors however have different behaviors in an RRCK assay to assess cell permeability.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligopeptides
/
Cyclosporine
Limits:
Animals
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2017
Document type:
Article