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Functionality of albumin-derived perfluorocarbon-based artificial oxygen carriers in the Langendorff-heart †.
Wrobeln, Anna; Schlüter, Klaus D; Linders, Jürgen; Zähres, Manfred; Mayer, Christian; Kirsch, Michael; Ferenz, Katja B.
Affiliation
  • Wrobeln A; a Institute for Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen , Essen , Germany.
  • Schlüter KD; b Institute of Physiology, Justus-Liebig-University , Giessen , Germany.
  • Linders J; c Institute for Physical Chemistry, University of Duisburg-Essen, CeNIDE , Essen , Germany.
  • Zähres M; c Institute for Physical Chemistry, University of Duisburg-Essen, CeNIDE , Essen , Germany.
  • Mayer C; c Institute for Physical Chemistry, University of Duisburg-Essen, CeNIDE , Essen , Germany.
  • Kirsch M; a Institute for Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen , Essen , Germany.
  • Ferenz KB; a Institute for Physiological Chemistry, University Hospital Essen, University of Duisburg-Essen , Essen , Germany.
Artif Cells Nanomed Biotechnol ; 45(4): 723-730, 2017 Jun.
Article in En | MEDLINE | ID: mdl-28278587
ABSTRACT
The aim of this study was to prove whether albumin-derived perfluorocarbon-based nanoparticles (capsules) can operate as a novel artificial oxygen carrier in a rat Langendorff-heart perfusion model. Hearts perfused with capsules showed increased left ventricular pressure and rate pressure product compared to hearts perfused with pure Krebs-Henseleit (KH)-buffer. The capsules prevented the myocardium from functional fail when in their absence a noxious ischemia was observed. Capsules did not change rheological properties of KH-buffer and could repeatedly reload with oxygen. This albumin-derived perfluorocarbon-based artificial oxygen carrier preserved the function of rat hearts due to the transport of oxygen in a satisfactory manner. Because of these positive results, the functionality of the applied capsules should be verified in living animals.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Substitutes / Albumins / Fluorocarbons / Heart Limits: Animals Language: En Journal: Artif Cells Nanomed Biotechnol Year: 2017 Document type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Substitutes / Albumins / Fluorocarbons / Heart Limits: Animals Language: En Journal: Artif Cells Nanomed Biotechnol Year: 2017 Document type: Article Affiliation country: Germany