Transdermal delivery of oleanolic acid attenuates pro-inflammatory cytokine release and ameliorates anaemia in P. berghei malaria.

Sibiya, Happiness; Musabayane, Cephas T; Mabandla, Musa V

Sibiya, Happiness; Musabayane, Cephas T; Mabandla, Musa V.

Affiliation

Sibiya H; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa. Electronic address: 208512882@stu.ukzn.ac.za.
Musabayane CT; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
Mabandla MV; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.

Acta Trop ; 171: 24-29, 2017 Jul.

Article in En | MEDLINE | ID: mdl-28283442

Subject(s)

Anemia/prevention & control; Cytokines/metabolism; Inflammation/drug therapy; Malaria/veterinary; Oleanolic Acid/pharmacology; Animals; Cytokines/blood; Cytokines/genetics; Gene Expression Regulation/drug effects; Inflammation/metabolism; Interleukin-10; Interleukin-6; Malaria/drug therapy; Malaria/parasitology; Male; Oleanolic Acid/administration & dosage; Parasitemia/parasitology; Plasmodium berghei/drug effects; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

Key words

Anaemia; Cytokines; Inflammation; Malaria; Oleanolic acid; Plasmodium berghei; Transdermal patch

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Cytokines / Inflammation / Anemia / Malaria Limits: Animals Language: En Journal: Acta Trop Year: 2017 Document type: Article Country of publication: Netherlands

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