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Benzofuran glycosides and coumarins from the bark of Streblus indicus (Bur.) Corner.
He, Ruijie; Zhang, Yanjun; Wu, Liangdeng; Nie, Hui; Huang, Yan; Liu, Buming; Deng, Shengping; Yang, Ruiyun; Huang, Shuai; Nong, Zhijie; Li, Jun; Chen, Haiyan.
Affiliation
  • He R; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China; Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guilin, 541006
  • Zhang Y; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
  • Wu L; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
  • Nie H; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
  • Huang Y; Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning, 530022, PR China.
  • Liu B; Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning, 530022, PR China.
  • Deng S; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
  • Yang R; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
  • Huang S; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
  • Nong Z; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China.
  • Li J; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy of Guangxi Normal University, Guilin, 541004, PR China. Electronic address: lijun9593@gxnu.edu.cn.
  • Chen H; Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, PR China. Electronic address: czyzsu@163.com.
Phytochemistry ; 138: 170-177, 2017 Jun.
Article in En | MEDLINE | ID: mdl-28284566
ABSTRACT
Two pairs of rare benzofuran glucoside epimers, indicuses A and B and indicuses C and D, three biogenetically related compounds indicuses E-G, and one coumarin indicus H, as well as 11 known compounds, were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of indicuses A-H were elucidated by NMR and MS data, as well as by CD. (S)-Marmesinin exhibited moderate antimicrobial activity in vitro against Bacillus subtilis and Saccharomyces cerevisiae. 7,8-Dihydroxy-3-(3-methyl-2-butenyl) coumarin, umbelliferone, and scopoletin displayed strong cytotoxic activity in vitro against human bladder carcinoma cell line EJ. The structure-activity relationships indicate that hydroxylation at C-7 in the cytotoxic compounds is crucial to their activities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzofurans / Coumarins / Moraceae / Glycosides Limits: Humans Language: En Journal: Phytochemistry Year: 2017 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzofurans / Coumarins / Moraceae / Glycosides Limits: Humans Language: En Journal: Phytochemistry Year: 2017 Document type: Article