Structure-activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity.

Vaara, Martti; Vaara, Timo; Tyrrell, Jonathan M

Vaara, Martti; Vaara, Timo; Tyrrell, Jonathan M.

Affiliation

Vaara M; Northern Antibiotics Ltd., FI-02150 Espoo, Finland; Division of Clinical Microbiology, Helsinki University Hospital, FI-00029 Helsinki, Finland; Department of Bacteriology and Immunology, Helsinki University Medical School, FI-00014 Helsinki, Finland. Electronic address: martti.vaara@northernantibiotics.com.
Vaara T; Northern Antibiotics Ltd., FI-02150 Espoo, Finland.
Tyrrell JM; Department of Medical Microbiology & Infectious Disease, Institute of Infection & Immunity, UGW Main Building, Heath Park Campus, Cardiff, Wales, UK.

Peptides ; 91: 8-12, 2017 05.

Article in En | MEDLINE | ID: mdl-28300674

Subject(s)

Anti-Bacterial Agents/pharmacology; Bacteria/drug effects; Polymyxins/analogs & derivatives; Animals; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/urine; Cell Line; Dose-Response Relationship, Drug; Kidney/drug effects; Macaca fascicularis; Polymyxins/chemistry; Polymyxins/pharmacology; Polymyxins/urine; Rats; Structure-Activity Relationship

Key words

Acinetobacter baumannii; Escherichia coli; Excretion to urine; HK-2; Klebsiella pneumoniae; NAB739, NAB815; Nephrotoxicity; Pseudomonas aeruginosa

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteria / Polymyxins / Anti-Bacterial Agents Limits: Animals Language: En Journal: Peptides Year: 2017 Document type: Article Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google