Anti-human CD14 monoclonal antibody improves survival following sepsis induced by endotoxin, but not following polymicrobial infection.

Nakamura, Masaki; Takeuchi, Takashi; Shirakawa, Kamon; Furusako, Shoji

Nakamura, Masaki; Takeuchi, Takashi; Shirakawa, Kamon; Furusako, Shoji.

Affiliation

Nakamura M; Discovery Research, Mochida Pharmaceutical Co., Ltd., Shizuoka, Japan. Electronic address: mnakamur@mochida.co.jp.
Takeuchi T; Discovery Research, Mochida Pharmaceutical Co., Ltd., Shizuoka, Japan.
Shirakawa K; Discovery Research, Mochida Pharmaceutical Co., Ltd., Shizuoka, Japan.
Furusako S; Discovery Research, Mochida Pharmaceutical Co., Ltd., Shizuoka, Japan.

Eur J Pharmacol ; 806: 18-24, 2017 Jul 05.

Article in En | MEDLINE | ID: mdl-28322834

Subject(s)

Antibodies, Monoclonal/immunology; Endotoxins/toxicity; Lipopolysaccharide Receptors/immunology; Sepsis/immunology; Animals; Blood Coagulation/drug effects; Coinfection/drug therapy; Coinfection/microbiology; Epitopes/immunology; Humans; Interleukin-6/biosynthesis; Leukocytes/drug effects; Leukocytes/immunology; Leukocytes/metabolism; Male; Rabbits; Rats; Sepsis/chemically induced; Sepsis/metabolism; Sepsis/physiopathology; Survival Analysis

Key words

Coagulation; Hemostasis; Inflammation; Lipopolysaccharide; Lipopolysaccharide (PubChem CID: 11970143); Mortality

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sepsis / Lipopolysaccharide Receptors / Endotoxins / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Eur J Pharmacol Year: 2017 Document type: Article Country of publication: Netherlands

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