Analysis of the non-stationarity of neural activity during an auditory oddball task in schizophrenia.
Annu Int Conf IEEE Eng Med Biol Soc
; 2016: 3724-3727, 2016 Aug.
Article
in En
| MEDLINE
| ID: mdl-28324996
ABSTRACT
The aim of this study was to characterize brain dynamics during an auditory oddball task. For this purpose, a measure of the non-stationarity of a given time-frequency representation (TFR) was applied to electroencephalographic (EEG) signals. EEG activity was acquired from 20 schizophrenic (SCH) patients and 20 healthy controls while they underwent a three-stimulus auditory oddball task. The Degree of Stationarity (DS), a measure of the non-stationarity of the TFR, was computed using the continuous wavelet transform. DS was calculated for both the baseline [-300 0] ms and active task [150 550] ms windows of a P300 auditory oddball task. Results showed a statistically significant increase (p<;0.05) in non-stationarity for controls during the cognitive task in the central region, while less widespread statistically significant differences were obtained for SCH patients, especially in the beta-2 and gamma bands. Our findings support the relevance of DS as a means to study cerebral processing in SCH. Furthermore, the lack of statistically significant changes in DS for SCH patients suggests an abnormal reorganization of neural dynamics during an oddball task.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
/
Acoustic Stimulation
/
Signal Processing, Computer-Assisted
/
Electroencephalography
Type of study:
Observational_studies
Limits:
Adult
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Female
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Humans
/
Male
Language:
En
Journal:
Annu Int Conf IEEE Eng Med Biol Soc
Year:
2016
Document type:
Article