Induction of T-Cell Infiltration and Programmed Death Ligand 2 Expression by Adeno-Associated Virus in Rhesus Macaque Skeletal Muscle and Modulation by Prednisone.

Cramer, Megan L; Shao, Guohong; Rodino-Klapac, Louise R; Chicoine, Louis G; Martin, Paul T

Cramer, Megan L; Shao, Guohong; Rodino-Klapac, Louise R; Chicoine, Louis G; Martin, Paul T.

Affiliation

Cramer ML; 1 Molecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University , Columbus, Ohio.
Shao G; 2 Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital , Columbus, Ohio.
Rodino-Klapac LR; 3 Department of Pediatrics, The Ohio State University College of Medicine , Columbus, Ohio.
Chicoine LG; 2 Center for Gene Therapy, The Research Institute at Nationwide Children's Hospital , Columbus, Ohio.
Martin PT; 3 Department of Pediatrics, The Ohio State University College of Medicine , Columbus, Ohio.

Hum Gene Ther ; 28(6): 493-509, 2017 06.

Article in En | MEDLINE | ID: mdl-28345428

Subject(s)

Dependovirus/genetics; Genetic Vectors/immunology; Immunosuppressive Agents/pharmacology; Muscular Dystrophies/therapy; Prednisone/pharmacology; Programmed Cell Death 1 Ligand 2 Protein/genetics; Programmed Cell Death 1 Receptor/genetics; Administration, Oral; Animals; CD8-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/pathology; Capsid Proteins/genetics; Capsid Proteins/immunology; Cell Death; Dependovirus/immunology; Gene Expression; Genetic Therapy/methods; Genetic Vectors/administration & dosage; Genetic Vectors/chemistry; Immunity, Cellular/drug effects; Injections, Intra-Arterial; Injections, Intramuscular; Macaca mulatta; Muscle, Skeletal/drug effects; Muscle, Skeletal/immunology; Muscle, Skeletal/pathology; Muscular Dystrophies/genetics; Muscular Dystrophies/immunology; Muscular Dystrophies/pathology; N-Acetylgalactosaminyltransferases/genetics; N-Acetylgalactosaminyltransferases/immunology; Programmed Cell Death 1 Ligand 2 Protein/agonists; Programmed Cell Death 1 Ligand 2 Protein/immunology; Programmed Cell Death 1 Receptor/agonists; Programmed Cell Death 1 Receptor/immunology; T-Lymphocytes, Regulatory/drug effects; T-Lymphocytes, Regulatory/immunology; T-Lymphocytes, Regulatory/pathology; Transgenes

Key words

AAV; PD1; gene therapy; lymphocyte; muscular dystrophy; neuromuscular junction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prednisone / Dependovirus / Programmed Cell Death 1 Ligand 2 Protein / Programmed Cell Death 1 Receptor / Genetic Vectors / Immunosuppressive Agents / Muscular Dystrophies Type of study: Risk_factors_studies Language: En Journal: Hum Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2017 Document type: Article

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