An in vitro approach for comparative interspecies metabolism of agrochemicals.
Regul Toxicol Pharmacol
; 88: 322-327, 2017 Aug.
Article
in En
| MEDLINE
| ID: mdl-28347762
ABSTRACT
The metabolism and elimination of a xenobiotic has a direct bearing on its potential to cause toxicity in an organism. The confidence with which data from safety studies can be extrapolated to humans depends, among other factors, upon knowing whether humans are systemically exposed to the same chemical entities (i.e. a parent compound and its metabolites) as the laboratory animals used to study toxicity. Ideally, to understand a metabolite in terms of safety, both the chemical structure and the systemic exposure would need to be determined. However, as systemic exposure data (i.e. blood concentration/time data of test material or metabolites) in humans will not be available for agrochemicals, an in vitro approach must be taken. This paper outlines an in vitro experimental approach for evaluating interspecies metabolic comparisons between humans and animal species used in safety studies. The aim is to ensure, where possible, that all potential human metabolites are also present in the species used in the safety studies. If a metabolite is only observed in human in vitro samples and is not present in a metabolic pathway defined in the toxicological species already, the toxicological relevance of this metabolite must be evaluated.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Agrochemicals
Limits:
Animals
/
Humans
Language:
En
Journal:
Regul Toxicol Pharmacol
Year:
2017
Document type:
Article
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS