Visualization and targeting of LGR5<sup>+</sup> human colon cancer stem cells.

Shimokawa, Mariko; Ohta, Yuki; Nishikori, Shingo; Matano, Mami; Takano, Ai; Fujii, Masayuki; Date, Shoichi; Sugimoto, Shinya; Kanai, Takanori; Sato, Toshiro

Visualization and targeting of LGR5⁺ human colon cancer stem cells.

Shimokawa, Mariko; Ohta, Yuki; Nishikori, Shingo; Matano, Mami; Takano, Ai; Fujii, Masayuki; Date, Shoichi; Sugimoto, Shinya; Kanai, Takanori; Sato, Toshiro.

Affiliation

Shimokawa M; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.
Ohta Y; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.
Nishikori S; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.
Matano M; Fujii Memorial Research Institute, Otsuka Pharmaceutical Company, Limited, Shiga, Japan.
Takano A; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.
Fujii M; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.
Date S; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.
Sugimoto S; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.
Kanai T; Fujii Memorial Research Institute, Otsuka Pharmaceutical Company, Limited, Shiga, Japan.
Sato T; Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan.

Nature ; 545(7653): 187-192, 2017 05 11.

Article in En | MEDLINE | ID: mdl-28355176

Subject(s)

Cell Tracking; Colonic Neoplasms/drug therapy; Colonic Neoplasms/pathology; Molecular Targeted Therapy; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/pathology; Receptors, G-Protein-Coupled/metabolism; Animals; Cell Differentiation; Cell Lineage; Cell Proliferation; Cell Self Renewal; Colonic Neoplasms/genetics; Colonic Neoplasms/metabolism; Gene Knock-In Techniques; Humans; Keratin-20/genetics; Keratin-20/metabolism; Male; Mice; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/transplantation; Organoids/metabolism; Organoids/pathology; Organoids/transplantation; Receptors, G-Protein-Coupled/genetics; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Colonic Neoplasms / Receptors, G-Protein-Coupled / Cell Tracking / Molecular Targeted Therapy Limits: Animals / Humans / Male Language: En Journal: Nature Year: 2017 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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