Role of Prolactin in the Regulation of Bicarbonates Biodynamics in Female Rat Model of Cholestasis of Pregnancy.
Bull Exp Biol Med
; 162(5): 611-614, 2017 Mar.
Article
in En
| MEDLINE
| ID: mdl-28361424
ABSTRACT
We studied possible involvement of prolactin in the regulation of bicarbonate biodynamics using female rat model of cholestasis of pregnancy induced by transplantation of the donor pituitary under the renal capsule of a recipient (hyperprolactinemia) and bile duct ligation (cholestasis). The concentration of bicarbonates in the bile and blood, their excretion, clearance, and reabsorption, as well as glomerular filtration rate and excretion of sodium ions were assessed. It was found that the main effect of prolactin was directed to the kidney-regulated pool of bicarbonates and consisted in stimulation of their clearance and inhibition of reabsorption, which led to a decrease in bicarbonate blood concentration. Parallel influence of prolactin on the clearance of bicarbonates and sodium ions was observed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications
/
Prolactin
/
Bicarbonates
/
Cholestasis, Intrahepatic
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Bull Exp Biol Med
Year:
2017
Document type:
Article
Affiliation country:
RUSSIA