Recent developments in the science of proarrhythmic cardiac safety of new drugs.

Turner, J Rick; Karnad, Dilip R; Cabell, Christopher H; Kothari, Snehal

Turner, J Rick; Karnad, Dilip R; Cabell, Christopher H; Kothari, Snehal.

Affiliation

Turner JR; Cardiac Safety Services, QuintilesIMS, 4820 Emperor Blvd, Durham, NC 27703, USA.
Karnad DR; Cardiac Safety Services, QuintilesIMS, 602 Western Express Highway, Andheri East, Mumbai 400 069, Maharashtra, India.
Cabell CH; Customer Solutions Management Group, QuintilesIMS, 4820 Emperor Blvd, Durham NC 27703, USA.
Kothari S; Cardiac Safety Services, Global Head, Cardiac Safety Center of Excellence, QuintilesIMS, 602 Western Express Highway, Andheri East, Mumbai 400 069, Maharashtra, India.

Eur Heart J Cardiovasc Pharmacother ; 3(2): 118-124, 2017 04 01.

Article in En | MEDLINE | ID: mdl-28363206

Subject(s)

Anti-Arrhythmia Agents/therapeutic use; Arrhythmias, Cardiac/drug therapy; Drug Evaluation/methods; Humans; Treatment Outcome

Key words

Brugada syndrome; Exposure-response modelling; Human induced pluripotent stem-cell derived cardiomyocytes ; In silico modelling; Short QT syndrome; T-wave morphology; Thorough QT/QTc study; Torsades de Pointes; Tpe

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arrhythmias, Cardiac / Drug Evaluation / Anti-Arrhythmia Agents Type of study: Guideline Limits: Humans Language: En Journal: Eur Heart J Cardiovasc Pharmacother Year: 2017 Document type: Article Affiliation country: United States Country of publication: United kingdom

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