Regression of Established Cardiac Fibrosis in Hypertensive Heart Disease.

Weber, Karl T; Sun, Yao; Gerling, Ivan C; Guntaka, Ramareddy V

Weber, Karl T; Sun, Yao; Gerling, Ivan C; Guntaka, Ramareddy V.

Affiliation

Weber KT; Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Sun Y; Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Gerling IC; Division of Endocrinology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Guntaka RV; Department of Microbiology, Immunology & Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Am J Hypertens ; 30(11): 1049-1052, 2017 Nov 01.

Article in En | MEDLINE | ID: mdl-28379281

ABSTRACT

Established cardiac fibrosis (ECF) with symptomatic heart failure preserved ejection fraction represents an ever-increasing segment of the hypertensive population. The regression of ECF with attendant improvement in myocardial stiffness and symptomatic failure represents an unmet health care need. Is the regression of ECF in hypertensive heart disease feasible and will stiffness and symptomatic failure be improved? What is the cellular/molecular signaling involved in its regression? What incremental knowledge is needed to proceed effectively? These issues are addressed in this Review.

Subject(s)

Blood Pressure; Cardiomyopathies/etiology; Heart Failure/etiology; Hypertension/complications; Myocardium/pathology; Ventricular Remodeling; Animals; Antihypertensive Agents/therapeutic use; Cardiomyopathies/metabolism; Cardiomyopathies/pathology; Cardiomyopathies/physiopathology; Fibrosis; Heart Failure/pathology; Heart Failure/physiopathology; Humans; Hypertension/diagnosis; Hypertension/drug therapy; Hypertension/physiopathology; Myocardium/metabolism; Myofibroblasts/metabolism; Myofibroblasts/pathology; Remission Induction; Signal Transduction; Treatment Outcome; Ventricular Remodeling/drug effects

Key words

blood pressure; cardiac fibrosis; hypertension; hypertensive heart disease; molecular signaling with fibrogenic and fibrolytic axes; myocardial stiffness; myofibroblast secretome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Pressure / Ventricular Remodeling / Heart Failure / Hypertension / Cardiomyopathies / Myocardium Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Am J Hypertens Journal subject: ANGIOLOGIA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States

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